Publications

2019

• Local decay for weak interactions with massless particles
  
  • Barbaroux Jean-Marie
  • Faupin Jérémy
  • Guillot Jean-Claude
  Journal of Spectral Theory, European Mathematical Society, 2019, 9 (2), pp.453–512. We consider a mathematical model for the weak decay of the intermediate boson $Z^0$ into neutrinos and antineutrinos. We prove that the total Hamiltonian has a unique ground state in Fock space and we establish a limiting absorption principle, local decay and a property of relaxation to the ground state for initial states and observables suitably localized in energy and position. Our proofs rest, in particular, on Mourre's theory and a low-energy decomposition. (10.4171/JST/253)
  DOI : 10.4171/JST/253
• Uniform propagation of chaos and creation of chaos for a class of nonlinear diffusions
  
  • del Moral Pierre
  • Tugaut Julian
  Stochastic Analysis and Applications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2019, 37 (6), pp.909-935. We are interested in nonlinear diffusions in which the own law intervenes in the drift. This kind of diffusions corresponds to the hydrodynamical limit of some particle system. One also talks about propagation of chaos. It is well known, for McKean-Vlasov diffusions, that such a propagation of chaos holds on finite-time interval. We here aim to establish a uniform propagation of chaos even if the external force is not convex, with a diffusion coefficient sufficiently large. The idea consists in combining the propagation of chaos on a finite-time interval with a functional inequality, already used by Bolley, Gentil and Guillin. Here, we also deal with a case in which the system at time t = 0 is not chaotic and we show under easily checked assumptions that the system becomes chaotic as the number of particles goes to infinity together with the time. This yields the first result of this type for mean field particle diffusion models as far as we know. (10.1080/07362994.2019.1622426)
  DOI : 10.1080/07362994.2019.1622426
• The Homogenization Method for Topology Optimization of Structures: Old and New
  
  • Allaire Grégoire
  • Cavallina Lorenzo
  • Miyake Nobuhito
  • Oka Tomoyuki
  • Yachimura Toshiaki
  Interdisciplinary Information Sciences, Editorial Committee of the Interdisciplinary Information Sciences, 2019, 25 (2), pp.75-146. (10.4036/iis.2019.B.01)
  DOI : 10.4036/iis.2019.B.01
• Analysis of Langevin Monte Carlo via convex optimization
  
  • Durmus Alain
  • Majewski Szymon
  • Miasojedow Błażej
  Journal of Machine Learning Research, Microtome Publishing, 2019. In this paper, we provide new insights on the Unadjusted Langevin Algorithm. We show that this method can be formulated as a first order optimization algorithm of an objective functional defined on the Wasserstein space of order $2$. Using this interpretation and techniques borrowed from convex optimization, we give a non-asymptotic analysis of this method to sample from logconcave smooth target distribution on $\mathbb{R}^d$. Based on this interpretation, we propose two new methods for sampling from a non-smooth target distribution, which we analyze as well. Besides, these new algorithms are natural extensions of the Stochastic Gradient Langevin Dynamics (SGLD) algorithm, which is a popular extension of the Unadjusted Langevin Algorithm. Similar to SGLD, they only rely on approximations of the gradient of the target log density and can be used for large-scale Bayesian inference.
• A two-phase two-fluxes degenerate Cahn-Hilliard model as constrained Wasserstein gradient flow
  
  • Cancès Clément
  • Matthes Daniel
  • Nabet Flore
  Archive for Rational Mechanics and Analysis, Springer Verlag, 2019, 233 (2), pp.837–866. We study a non-local version of the Cahn-Hilliard dynamics for phase separation in a two-component incompressible and immiscible mixture with linear mobilities. In difference to the celebrated local model with nonlinear mobility, it is only assumed that the divergences of the two fluxes --- but not necessarily the fluxes themselves --- annihilate each other. Our main result is a rigorous proof of existence of weak solutions. The starting point is the formal representation of the dynamics as a constrained gradient flow in the Wasserstein metric. We then show that time-discrete approximations by means of the incremental minimizing movement scheme converge to a weak solution in the limit. Further, we compare the non-local model to the classical Cahn-Hilliard model in numerical experiments. Our results illustrate the significant speed-up in the decay of the free energy due to the higher degree of freedom for the velocity fields. (10.1007/s00205-019-01369-6)
  DOI : 10.1007/s00205-019-01369-6
• Avis en réponse à la saisine HCB sur le dossier EFSA-GMO-ES-2018-154. Paris, le 5 avril 2019
  
  • Comité Scientifique Du Haut Conseil Des Biotechnologies .
  • Angevin Frédérique
  • Bagnis Claude
  • Bar-Hen Avner
  • Barny Marie-Anne
  • Boireau Pascal
  • Brévault Thierry
  • Chauvel Bruno B.
  • Collonnier Cécile
  • Couvet Denis
  • Dassa Elie
  • de Verneuil Hubert
  • Demeneix Barbara
  • Franche Claudine
  • Guerche Philippe
  • Guillemain Joël
  • Hernandez Raquet Guillermina
  • Khalife Jamal
  • Klonjkowski Bernard
  • Lavielle Marc
  • Le Corre Valérie
  • Lefèvre François
  • Lemaire Olivier
  • Lereclus Didier D.
  • Maximilien Rémy
  • Meurs Eliane
  • Naffakh Nadia
  • Négre Didier
  • Noyer Jean-Louis
  • Ochatt Sergio
  • Pages Jean-Christophe
  • Raynaud Xavier
  • Regnault-Roger Catherine
  • Renard Michel M.
  • Renault Tristan
  • Saindrenan Patrick
  • Simonet Pascal
  • Troadec Marie-Bérengère
  • Vaissière Bernard
  • Vilotte Jean-Luc
  , 2019, pp.14 p..
• Topological derivative for the nonlinear magnetostatic problem
  
  • Amstutz Samuel
  • Gangl Peter
  Electronic Transactions on Numerical Analysis, Kent State University Library, 2019, 51, pp.169-218. (10.1553/etna_vol51s169)
  DOI : 10.1553/etna_vol51s169
• Initiation of a validation strategy of reduced-order two-fluid flow models using direct numerical simulations in the context of jet atomization
  
  • Cordesse Pierre
  • Murrone A.
  • Ménard T.
  • Massot Marc
  NASA Technical Memorandum, National Aeronautics and Space Administration, 2019, pp.1-11. In industrial applications, developing predictive tools relying on numerical simulations using reduced-order models nourish the need of building a validation strategy. In the context of cryogenic atomization, we propose to build a hierarchy of direct numerical simulation test cases to assess qualitatively and quantitatively diffuse interface models. The present work proposes an initiation of the validation strategy with an air-assisted water atomization using a coaxial injector.
• On a Wasserstein-type distance between solutions to stochastic differential equations
  
  • Bion-Nadal Jocelyne
  • Talay Denis
  The Annals of Applied Probability, Institute of Mathematical Statistics (IMS), 2019, 29 (3), pp.1609-1639. In this paper, we introduce a Wasserstein-type distance on the set of the probability distributions of strong solutions to stochastic differential equations. This new distance is defined by restricting the set of possible coupling measures. We prove that it may also be defined by means of the value function of a stochastic control problem whose Hamilton–Jacobi–Bellman equation has a smooth solution, which allows one to deduce a priori estimates or to obtain numerical evaluations. We exhibit an optimal coupling measure and characterize it as a weak solution to an explicit stochastic differential equation, and we finally describe procedures to approximate this optimal coupling measure. A notable application concerns the following modeling issue: given an exact diffusion model, how to select a simplified diffusion model within a class of admissible models under the constraint that the probability distribution of the exact model is preserved as much as possible? (10.1214/18-AAP1423)
  DOI : 10.1214/18-AAP1423
• Derivation of a two-phase flow model with two-scale kinematics, geometric variables and surface tension using variational calculus
  
  • Cordesse Pierre
  • Kokh Samuel
  • Di Battista Ruben
  • Drui Florence
  • Massot Marc
  NASA Technical Memorandum, National Aeronautics and Space Administration, 2019. The present paper proposes a two-phase flow model that is able to account for two-scale kinematics and two-scale surface tension effects based on geometric variables at small scale. At large scale, the flow and the full geometry of the interface may be retrieved thanks to the bulk variables, while at small scale the interface is accurately described by volume fraction, interfacial area density and mean curvature, called the geometric variables. Our work mainly relies on the Least Action Principle. The resulting system is an extension of a previous work modeling small scale pulsation in which surface tension was not taken into account at large or small scale. Whereas the original derivation assumes a cloud of monodispersed spherical bubbles, the present context allows for polydispersed, non-spherical bubbles. The resulting system of equations solely involves small scale geometric variables, thus contributing in the construction of a unified model describing both large and small scales.
• Pointwise Besov Space Smoothing of Images
  
  • Buzzard Gregery
  • Chambolle Antonin
  • Cohen Jonathan
  • Levine Stacey
  • Lucier Bradley
  Journal of Mathematical Imaging and Vision, Springer Verlag, 2019, 61 (1), pp.1-20. (10.1007/s10851-018-0821-1)
  DOI : 10.1007/s10851-018-0821-1
• On the stability of matrix-valued Riccati diffusions
  
  • Bishop Adrian N
  • del Moral Pierre
  Electronic Journal of Probability, Institute of Mathematical Statistics (IMS), 2019, 24. The stability properties of matrix-valued Riccati diffusions are investigated. The matrix-valued Riccati diffusion processes considered in this work are of interest in their own right, as a rather prototypical model of a matrix-valued quadratic stochastic process. Under rather natural observability and controllability conditions, we derive time-uniform moment and fluctuation estimates and exponential contraction inequalities. Our approach combines spectral theory with nonlinear semigroup methods and stochastic matrix calculus. This analysis seem to be the first of its kind for this class of matrix-valued stochastic differential equation. This class of stochastic models arise in signal processing and data assimilation, and more particularly in ensemble Kalman-Bucy filtering theory. In this context, the Riccati diffusion represents the flow of the sample covariance matrices associated with McKean-Vlasov-type interacting Kalman-Bucy filters. The analysis developed here applies to filtering problems with unstable signals. (10.1214/19-EJP342)
  DOI : 10.1214/19-EJP342
• Avis en réponse à la saisine HCB - EFSA-GMO-ES-2018-154. Paris, le 5 avril 2019
  
  • Du Haut Conseil Des Biotechnologies Comité Scientifique
  • Angevin Frédérique
  • Bagnis Claude
  • Bar-Hen Avner
  • Barny Marie-Anne
  • Boireau Pascal
  • Brévault Thierry
  • Chauvel Bruno B.
  • Collonnier Cécile
  • Couvet Denis
  • Dassa Elie
  • de Verneuil Hubert
  • Demeneix Barbara
  • Franche Claudine
  • Guerche Philippe
  • Guillemain Joël
  • Hernandez Raquet Guillermina
  • Khalife Jamal
  • Klonjkowski Bernard
  • Lavielle Marc
  • Le Corre Valérie
  • Lefèvre François
  • Lemaire Olivier
  • Lereclus Didier D.
  • Maximilien Rémy
  • Meurs Eliane
  • Naffakh Nadia
  • Négre Didier
  • Noyer Jean-Louis
  • Ochatt Sergio
  • Pages Jean-Christophe
  • Raynaud Xavier
  • Regnault-Roger Catherine
  • Renard Michel M.
  • Renault Tristan
  • Saindrenan Patrick
  • Simonet Pascal
  • Troadec Marie-Bérengère
  • Vaissière Bernard
  • Vilotte Jean-Luc
  , 2019.
• Avis en réponse à la saisine HCB - habilitation agents 2019. Paris, le 4 juillet 2019
  
  • Comité Scientifique Du Haut Conseil Des Biotechnologies .
  • Angevin Frédérique
  • Bagnis Claude
  • Bar-Hen Avner
  • Barny Marie-Anne
  • Boireau Pascal
  • Brévault Thierry
  • Chauvel Bruno B.
  • Collonnier Cécile
  • Couvet Denis
  • Dassa Elie
  • de Verneuil Hubert
  • Demeneix Barbara
  • Franche Claudine
  • Guerche Philippe
  • Guillemain Joël
  • Hernandez Raquet Guillermina
  • Khalife Jamal
  • Klonjkowski Bernard
  • Lavielle Marc
  • Le Corre Valérie
  • Lefèvre François
  • Lemaire Olivier
  • Lereclus Didier D.
  • Maximilien Rémy
  • Meurs Eliane
  • Naffakh Nadia
  • Négre Didier
  • Noyer Jean-Louis
  • Ochatt Sergio
  • Pages Jean-Christophe
  • Raynaud Xavier
  • Regnault-Roger Catherine
  • Renard Michel M.
  • Renault Tristan
  • Saindrenan Patrick
  • Simonet Pascal
  • Troadec Marie-Bérengère
  • Vaissière Bernard
  • Vilotte Jean-Luc
  , 2019, pp.2 p..
• Avis en réponse à la saisine HCB - dossier EFSA-GMO-RX-013. Paris, le 30 janvier 2019
  
  • Comité Scientifique Du Haut Conseil Des Biotechnologies .
  • Angevin Frédérique
  • Bagnis Claude
  • Bar-Hen Avner
  • Barny Marie-Anne
  • Boireau Pascal
  • Brévault Thierry
  • Chauvel Bruno B.
  • Collonnier Cécile
  • Couvet Denis
  • Dassa Elie
  • de Verneuil Hubert
  • Demeneix Barbara
  • Franche Claudine
  • Guerche Philippe
  • Guillemain Joël
  • Hernandez Raquet Guillermina
  • Khalife Jamal
  • Klonjkowski Bernard
  • Lavielle Marc
  • Le Corre Valérie
  • Lefèvre François
  • Lemaire Olivier
  • Lereclus Didier D.
  • Maximilien Rémy
  • Meurs Eliane
  • Naffakh Nadia
  • Négre Didier
  • Noyer Jean-Louis
  • Ochatt Sergio
  • Pages Jean-Christophe
  • Raynaud Xavier
  • Regnault-Roger Catherine
  • Renard Michel M.
  • Renault Tristan
  • Saindrenan Patrick
  • Simonet Pascal
  • Troadec Marie-Bérengère
  • Vaissière Bernard
  • Vilotte Jean-Luc
  , 2019.
• Mean field model for collective motion bistability
  
  • Garnier Josselin
  • Papanicolaou George
  • Yang Tzu-Wei
  Discrete and Continuous Dynamical Systems - Series B, American Institute of Mathematical Sciences, 2019, 24 (2), pp.851-879. (10.3934/dcdsb.2018210)
  DOI : 10.3934/dcdsb.2018210
• Existence of strong solutions to the Dirichlet problem for the Griffith energy
  
  • Chambolle Antonin
  • Crismale Vito
  Calculus of Variations and Partial Differential Equations, Springer Verlag, 2019, 58 (136). In this paper we continue the study of the Griffith brittle fracture energy minimisation under Dirichlet boundary conditions, suggested by Francfort and Marigo in 1998. In a recent paper, we proved the existence of weak minimisers of the problem. Now we show that these minimisers are indeed strong solutions, namely their jump set is closed and they are smooth away from the jump set and continuous up to the Dirichlet boundary. This is obtained by extending up to the boundary the recent regularity results of Conti, Focardi, Iurlano, and of Chambolle, Conti, Iurlano. (10.1007/s00526-019-1571-7)
  DOI : 10.1007/s00526-019-1571-7
• Incomplete graphical model inference via latent tree aggregation
  
  • Robin Geneviève
  • Ambroise Christophe
  • Robin Stephane S.
  Statistical Modelling, SAGE Publications, 2019, 19 (5), pp.545-568. Graphical network inference is used in many fields such as genomics or ecology to infer the conditional independence structure between variables, from measurements of gene expression or species abundances for instance. In many practical cases, not all variables involved in the network have been observed, and the samples are actually drawn from a distribution where some variables have been marginalized out. This challenges the sparsity assumption commonly made in graphical model inference, since marginalization yields locally dense structures, even when the original network is sparse. We present a procedure for inferring Gaussian graphical models when some variables are unobserved, that accounts both for the influence of missing variables and the low density of the original network. Our model is based on the aggregation of spanning trees, and the estimation procedure on the Expectation-Maximization algorithm. We treat the graph structure and the unobserved nodes as missing variables and compute posterior probabilities of edge appearance. To provide a complete methodology, we also propose several model selection criteria to estimate the number of missing nodes. A simulation study and an illustration flow cytometry data reveal that our method has favorable edge detection properties compared to existing graph inference techniques. The methods are implemented in an R package. (10.1177/1471082X18786289)
  DOI : 10.1177/1471082X18786289
• Longest increasing paths with gaps
  
  • Basdevant Anne-Laure
  • Gerin Lucas
  ALEA : Latin American Journal of Probability and Mathematical Statistics, Instituto Nacional de Matemática Pura e Aplicada (Rio de Janeiro, Brasil) [2006-....], 2019, 16 (2), pp.1141--1163. We consider a variant of the continuous and discrete Ulam-Hammersley problems: we study the maximal length of an increasing path through a Poisson point process (or a Bernoulli point process) with the restriction that there must be minimal gaps between abscissae and ordinates of successive points of the path. For both cases (continuous and discrete) our approach rely on couplings with well-studied models: respectively the classical Ulam-Hammersley problem and last-passage percolation with geometric weights. Thanks to these couplings we obtain explicit limiting shapes in both settings. We also establish that, as in the classical Ulam-Hammersley problem, the fluctuations around the mean are given by the Tracy-Widom distribution.
• Statistical estimation in a randomly structured branching population
  
  • Hoffmann Marc
  • Marguet Aline
  Stochastic Processes and their Applications, Elsevier, 2019, 129 (12), pp.5236-5277. We consider a binary branching process structured by a stochastic trait that evolves according to a diffusion process that triggers the branching events, in the spirit of Kimmel's model of cell division with parasite infection. Based on the observation of the trait at birth of the first n generations of the process, we construct nonparametric estimator of the transition of the associated bifurcating chain and study the parametric estimation of the branching rate. In the limit $n → ∞$, we obtain asymptotic efficiency in the parametric case and minimax optimality in the nonparametric case. (10.1016/j.spa.2019.02.015)
  DOI : 10.1016/j.spa.2019.02.015
• C-mix: a high dimensional mixture model for censored durations, with applications to genetic data
  
  • Bussy Simon
  • Guilloux Agathe
  • Gaïffas Stéphane
  • Jannot Anne-Sophie
  Statistical Methods in Medical Research, SAGE Publications, 2019, 28 (5), pp.1523--1539. We introduce a supervised learning mixture model for censored durations (C-mix) to simultaneously detect subgroups of patients with different prognosis and order them based on their risk. Our method is applicable in a high-dimensional setting, i.e. with a large number of biomedical covariates. Indeed, we penalize the negative log-likelihood by the Elastic-Net, which leads to a sparse parameterization of the model and automatically pinpoints the relevant covariates for the survival prediction. Inference is achieved using an efficient Quasi-Newton Expectation Maximization (QNEM) algorithm, for which we provide convergence properties. The statistical performance of the method is examined on an extensive Monte Carlo simulation study, and finally illustrated on three publicly available genetic cancer datasets with high-dimensional co-variates. We show that our approach outperforms the state-of-the-art survival models in this context, namely both the CURE and Cox proportional hazards models penalized by the Elastic-Net, in terms of C-index, AUC(t) and survival prediction. Thus, we propose a powerfull tool for personalized medicine in cancerology. (10.1177/0962280218766389)
  DOI : 10.1177/0962280218766389
• Avis en réponse à la saisine HCB - dossier RX-015. Paris, le 26 février 2019
  
  • Comité Scientifique Du Haut Conseil Des Biotechnologies .
  • Angevin Frédérique
  • Bagnis Claude
  • Bar-Hen Avner
  • Barny Marie-Anne
  • Boireau Pascal
  • Brévault Thierry
  • Chauvel Bruno B.
  • Collonnier Cécile
  • Couvet Denis
  • Dassa Elie
  • de Verneuil Hubert
  • Demeneix Barbara
  • Franche Claudine
  • Guerche Philippe
  • Guillemain Joël
  • Hernandez Raquet Guillermina
  • Khalife Jamal
  • Klonjkowski Bernard
  • Lavielle Marc
  • Le Corre Valérie
  • Lefèvre François
  • Lemaire Olivier
  • Lereclus Didier D.
  • Maximilien Rémy
  • Meurs Eliane
  • Naffakh Nadia
  • Négre Didier
  • Noyer Jean-Louis
  • Ochatt Sergio
  • Pages Jean-Christophe
  • Raynaud Xavier
  • Regnault-Roger Catherine
  • Renard Michel M.
  • Renault Tristan
  • Saindrenan Patrick
  • Simonet Pascal
  • Troadec Marie-Bérengère
  • Vaissière Bernard
  • Vilotte Jean-Luc
  , 2019.
• Avis en réponse à la saisine HCB - dossier 2018-151. Paris, le 10 janvier 2019
  
  • Comité Scientifique Du Haut Conseil Des Biotechnologies .
  • Angevin Frédérique
  • Bagnis Claude
  • Bar-Hen Avner
  • Barny Marie-Anne
  • Boireau Pascal
  • Brévault Thierry
  • Chauvel Bruno B.
  • Collonnier Cécile
  • Couvet Denis
  • Dassa Elie
  • de Verneuil Hubert
  • Demeneix Barbara
  • Franche Claudine
  • Guerche Philippe
  • Guillemain Joël
  • Hernandez Raquet Guillermina
  • Khalife Jamal
  • Klonjkowski Bernard
  • Lavielle Marc
  • Le Corre Valérie
  • Lefèvre François
  • Lemaire Olivier
  • Lereclus Didier D.
  • Maximilien Rémy
  • Meurs Eliane
  • Naffakh Nadia
  • Négre Didier
  • Noyer Jean-Louis
  • Ochatt Sergio
  • Pages Jean-Christophe
  • Raynaud Xavier
  • Regnault-Roger Catherine
  • Renard Michel M.
  • Renault Tristan
  • Saindrenan Patrick
  • Simonet Pascal
  • Troadec Marie-Bérengère
  • Vaissière Bernard
  • Vilotte Jean-Luc
  , 2019.
• On the Essential Self-Adjointness of Singular Sub-Laplacians
  
  • Franceschi Valentina
  • Prandi Dario
  • Rizzi Luca
  Potential Analysis, Springer Verlag, 2019, 53, pp.89-112. (10.1007/s11118-018-09760-w)
  DOI : 10.1007/s11118-018-09760-w
• The asymptotic geometry of the Teichmüller metric
  
  • Walsh Cormac
  Geometriae Dedicata, Springer Verlag, 2019, 200 (1), pp.115-152. We determine the asymptotic behaviour of extremal length along arbitrary Teichmüller rays. This allows us to calculate the endpoint in the Gardiner-Masur boundary of any Teichmüller ray. We give a proof that this compactification is the same as the horofunction compactification. An important subset of the latter is the set of Busemann points. We show that the Busemann points are exactly the limits of the Teichmüller rays, and we give a necessary and sufficient condition for a sequence of Busemann points to converge to a Busemann point. Finally, we determine the detour metric on the boundary. (10.1007/s10711-018-0364-z)
  DOI : 10.1007/s10711-018-0364-z