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Pascale Changenet

CNRS researcher
Laboratoire d'Optique et Biosciences
CNRS UMR 7640 -INSERM U1182 - Ecole Polytechnique
91128 Palaiseau, Cedex, France

Room: 02-2015
Tel: (+33) 169 335 030
e-mail: Nous contacter


Research interests:

Light-induced processes in complex molecular systems
Folding dynamics of G-quadruplexes
Time-resolved circular dichroism
Femtosecond transient absorption spectroscopy


Since 2018: Executive board member of the CNRS technological "Femto" network
Since 2016: Executive board member of the GDR "Ultrafast Phenomena" [UP]


Since 2014: CNRS research position, Laboratoire d’Optique et Biosciences, UMR 7645, Ecole Polytechnique, Palaiseau.
2010-2014: CNRS research position, Laboratoire Francis Perrin URA 2453, CEA/Saclay.
2000-2010: CNRS research position, Département de Chimie UMR 8640, ENS, Paris.
1998-2000: CNRS research position, Laboratoire de Photophysique Moléculaire UPR 3361, University of Paris XI, Orsay.


Since 2018: Coordination of the "Fast processes and radiations" teaching module in Erasmus Mundus master SERP+, University of Paris-Saclay.
Since 2011: Ultrafast spectroscopy, Master 2 PCCPM and Erasmus mundus SERP−Chem, University of Paris-Saclay.
2008−2011: Photochemistry, Master 1 Chemistry ENS−UPMC, ENS−Paris.
2005−2008: Ultrafast spectrocopy, Master 2 Physico−Chimie Moléculaire, University of Paris XI, Orsay.


2011: HdR, University of Paris XI, Orsay.
1997-1998: Post-doc, University of Pennsylvania, USA.
1996-1997: Post-doc, University of Amsterdam, The Netherlands.
1993-1996: PhD, Laboratoire de Photophysique Moléculaire, University of Paris XI, Orsay.
1992-1993: Diploma thesis on Chemical Physics, University of Paris XI, Orsay.


CNRS Bronze medal in 2002

Selected publications:

Transient absorption in inorganic systems
M. Ha-Thi, G. Burdzinski, T. Pino, P. Changenet, Springer Handbook of Inorganic Photochemistry, Accepted

A comprehensive study of guanine excited state relaxation and photoreactivity in G-quadruplexes
L. Martinez-Fernandez, P. Changenet, A. Banyasz, T. Gustavsson, D. Markovitsi, R. Improta, J. Phys. Chem. Lett. 10, 6873 (2019) 

Size-Exclusion Mechanism Driving Host–Guest Interactions between Octahedral Rhenium Clusters and Cyclodextrins
A. A. Ivanov, C. Falaise, K. Laouer, F. Hache, P. Changenet, Y. V. Mironov, D. Landy, Y. Molard, S. Cordier, M. A. Shestopalov, M. Haouas, E. Cadot, Inorg. Chem. 58, 13184 (2019) 

Unveiling excited-state chirality of binaphthols by femtosecond circular dichroism and quantum-chemical calculations
M. Schmid, L. Martinez-Fernandez, D. Markovitsi, F. Santoro, F. Hache, R. Improta, P. Changenet, J. Phys. Chem. Lett. 10, 4089 (2019)

Ultrafast Electron Transfer in Complexes of Doxorubicin with Human Telomeric G-Quadruplexes and GC Duplexes Probed by Femtosecond Fluorescence Spectroscopy
P. Changenet-Barret, T. Gustavsson, D. Markovitsi, I. Manet, ChemPhysChem (2016) 17, 1264-1272.

Ultrafast Excited-State Deactivation of 8-Hydroxy-2 '-deoxyguanosine Studied by Femtosecond Fluorescence Spectroscopy and Quantum-Chemical Calculations
P. Changenet-Barret, T. Gustavsson, R. Improta, D. Markovitisi, Journal of Physical Chemistry A (2015) 119, 6131-6139.

Electronic Excitations in Guanine Quadruplexes
P. Changenet-Barret, Y. Hua, D. Markovitsi, Topics in Current Chemistry (2015) 356, 183-201

Ultrafast Carbonyl Motion of the Photoactive Yellow Protein Chromophore Probed by Femtosecond Circular Dichroism
L. Mendonca, F. Hache, P. Changenet-Barret, P. Plaza, H. Chosrowjan, S. Taniguchi, Y. Imamoto, Journal of the American Chemical Society (2013) 135, 14637-14643

The effect of size on the optical properties of guanine nanostructures: a femtosecond to nanosecond study
Y. Hua, P. Changenet-Barret, T. Gustavsson, D. Markovitsi, Physical Chemistry Chemical Physics (2013) 15, 7396-7402

Unravelling molecular mechanisms in the fluorescence spectra of doxorubicin in aqueous solution by femtosecond fluorescence spectroscopy
P. Changenet-Barret, T. Gustavsson, D. Markovitsi, I. Manet, S. Monti, Physical Chemistry Chemical Physics (2013) 15, 2937-2944

Optical Properties of Guanine Nanowires: Experimental and Theoretical Study
P. Changenet-Barret, E. Emanuele, T. Gustavsson, R. Improta, A. B. Kotlyar, D. Markovitsi, I. Vaya, K. Zakrzewska, D. Zikich, Journal of Physical Chemistry C (2010) 114, 14339-14346

Primary photodynamics of a biomimetic model of photoactive yellow protein (PYP)
P. Changenet-Barret, C. Loukou, C. Ley, F. Lacombat, P. Plaza, J.-M. Mallet, M. M. Martin, Physical Chemistry Chemical Physics (2010) 12, 13715-13723

Structural effects on the photoisomerization of PYP probed by ultrafast absorption spectroscopy of two point mutants
P. Changenet-Barret, P. Plaza, M. M. Martin, H. Chosrowjan, S. Taniguchi, N. Mataga, Y. Imamoto, M. Kataoka, Journal of Physical Chemistry C (2009) 113, 11605-11613