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Publications

Publications récentes

  • Coureux PD, Lazennec-Schurdevin C, Bourcier S, Mechulam Y, Schmitt E.Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation.
    Commun Biol. (2020) Feb 6;3(1):58. doi: 10.1038/s42003-020-0780-0.
     -Opuu V, Nigro G, Gaillard T, Schmitt E, Mechulam Y, Simonson T.Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power. PLoS Comput Biol. (2020) Jan 9;16(1):e1007600. doi: 10.1371/journal.pcbi.1007600. eCollection 2020 Jan.
     -Nigro G, Bourcier S, Lazennec-Schurdevin C, Schmitt E, Marlière P, Mechulam Y.Use of β3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J Struct Biol. (2019) Dec 17:107435. doi: 10.1016/j.jsb.2019.107435.
  • Heddi B, Cheong VV, Schmitt E, Mechulam Y, Phan AT. Recognition of different base tetrads by RHAU: X-ray crystal structure of the G4 recognition motif bound to the 3’-end tetrad of a DNA G-quadruplex. Journal of Structural Biology, Elsevier, (2019), pp.S1047-8477(19)30210-2. DOI : 10.1016/j.jsb.2019.10.001
  • Winnerdy FR, Bakalar B, Maity A, Vandana JJ, Mechulam Y, Schmitt E, Phan AT. NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes. Nucleic Acids Res., (2019), pp.gkz349. DOI : 10.1093/nar/gkz349
  • Bakalar B, Heddi B, Schmitt E, Mechulam Y, Phan AT. A Minimal Sequence for Left-Handed G-Quadruplex Formation. Angew Chem Int Ed Engl. (2019) Nov 27. doi: 10.1002/anie.201812628
  • Monestier A, Lazennec-Schurdevin C, Coureux PD, Mechulam Y, Schmitt E. Role of aIF1 in Pyrococcus abyssi translation initiation. Nucleic Acids Res. (2018) doi: 10.1093/nar/gky850.
  • Schmitt E, Bourgeois G, Gondry M, Aleksandrov A. Cyclization Reaction Catalyzed by Cyclodipeptide Synthases Relies on a Conserved Tyrosine Residue. Sci Rep. (2018) doi: 10.1038/s41598-018-25479-5.
  • Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec-Schurdevin, C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Crews CM, Alexandrova AY, Perelmuter VM, Cherdyntseva NV, Bièche I, Schmitt  E, Insall  RH, Gautreau A. A trimeric coiled coil protein promotes WASH complex assembly. EMBO J. (2018).  doi: 10.15252/embj.201797706.
  • Bourgeois G, Seguin J, Babin M, Belin P, Moutiez M, Mechulam Y, Gondry M and Schmitt E. Structural basis for partition of the cyclodipeptide synthases into two subfamilies. J. Struct. Biol. (2018) 203:17-26. doi: 10.1016/j.jsb.2018.03.001.
  • Monestier A, Aleksandrov A, Coureux PD, Panvert M, Mechulam Y, Schmitt E. The structure of an E. coli tRNAfMet A1-U72 variant shows an unusual conformation of the A1-U72 base pair. RNA. (2017) doi: 10.1261/rna.057877.116.
  • Coureux PD, Lazennec-Schurdevin C, Monestier A, Larquet E, Cladière L, Klaholz BP, Schmitt E, Mechulam Y. (2016) Cryo-EM study of start codon selection during archaeal translation initiation. Nat Commun. 7:13366. doi: 10.1038/ncomms13366.
  • Panvert M, Dubiez E, Arnold L, Perez J, Mechulam Y, Seufert W, Schmitt E. (2015) Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features. Structure. 23:1596-1608.
  • Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT. (2015) Structure of a left-handed DNA G-quadruplex. Proc Natl Acad Sci U S A.,112. 2729-2733.
  • Dubiez E, Aleksandrov A, Lazennec-Schurdevin C, Mechulam Y, Schmitt E. (2015) Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2. Nucleic Acids Res., 43. 2946-2957.
  • Moutiez M, Schmitt E, Seguin J, Thai R, Favry E, Belin P, Mechulam Y, Gondry M. (2014). Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases. Nat Commun., 5:5141.
  • Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O (2013). Capturing the mutational landscape of the beta-lactamase TEM-1. Proc Natl Acad Sci U S A, 110(32):13067-72.
  • Naveau M, Lazennec-Schurdevin C, Panvert M, Dubiez E, Mechulam Y, Schmitt E (2013). Roles of yeast eIF2α and eIF2β subunits in the binding of the initiator methionyl-tRNA. Nucleic Acids Res., 41(2):1047-57.
  • E. Schmitt, M. Panvert, C. Lazennec-Schurdevin, P-D Coureux, J. Perez, A. Thompson and Y. Mechulam (2012). Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA. Nature Structural and Molecular Biology, Nat. Struct. Mol. Biol., 9, 450-45.
  • Schmitt E, Naveau M, Mechulam Y. (2010). Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier. FEBS Lett. 584:405-12. Invited review. 
  • Naveau M, Lazennec-Schurdevin C, Panvert M, Mechulam Y, Schmitt E. (2010). tRNA binding properties of eukaryotic initiation factor 2 from Encephalitozoon cuniculi. Biochemistry, 49:8680-8688.