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Publications

Recent publications :

  • Fedry J, Silva J, Vanevic M, Fronik S, Mechulam Y, Schmitt E, des Georges A, Faller WJ, Förster F. Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells.   Mol Cell. 2024 Mar 21;84(6):1078-1089.e4, doi.org/10.1016/j.molcel.2024.01.015.
     
  • Opuu V, Nigro G, Lazennec-Schurdevin C, Mechulam Y, Schmitt E, Simonson T. Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments.   Protein Sci. 2023 Sep;32(9):e4738, doi.org/10.1002/pro.4738.
     
  • Cardenal Peralta C, Vandroux P, Neumann-Arnold L, Panvert M, Fagart J, Seufert W, Mechulam Y, Schmitt E. Binding of human Cdc123 to eIF2γ.  J Struct Biol. 2023 Sep;215(3):108006, doi.org/10.1016/j.jsb.2023.108006.
     
  • Gabel F, Engilberge S, Schmitt E, Thureau A, Mechulam Y, Pérez J, Girard E. Medical contrast agents as promising tools for biomacromolecular SAXS experiments.  Acta Crystallogr D Struct Biol, 2022, 78, 1120-1130, doi.org/10.1107/S2059798322007392.
     
  • Gabel F, Engilberge S, Schmitt E, Thureau A, Mechulam Y, Pérez J, Girard E. Medical contrast agents as promising tools for biomacromolecular SAXS experiments.  Acta Crystallogr D Struct Biol, 2022, 78, 1120-1130, doi.org/10.1107/S2059798322007392.
     
  • Kazan R, Bourgeois G, Carisetti D, Florea I, Larquet E, Maurice JL, Mechulam Y, Ozanam F, Schmitt E, Coureux PD. Grid batch-dependent tuning of glow discharge parameters.  Front Mol Biosci. 2022, 18;9:910218, doi.org/10.3389/fmolb.2022.910218.
     
  • Kazan R, Bourgeois G, Lazennec-Schurdevin C, Larquet E, Mechulam Y, Coureux PD, Schmitt E. Role of aIF5B in archaeal translation initiation.  Nucleic Acids Res. 2022, 50, 6532–6548, doi.org/10.1093/nar/gkac490.
     
  • Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT. Bulges in left-handed G-quadruplexes.  Nucleic Acids Res. 2021 Feb 22;49(3):1724-1736, doi.org/10.1093/nar/gkaa1259.
     
  • Bourgeois G, Seguin J, Babin M, Gondry M, Mechulam Y, Schmitt E. Structural basis of the interaction between cyclodipeptide synthases and aminoacylated tRNA substrates. RNA. 2020 Jul 17:rna.075184.120, doi.org/10.1261/rna.075184.120.
     
  • Schmitt, E, Coureux, P-D, Kazan, R., Bourgeois, G., Lazennec-Schurdevin, C., Mechulam, Y. Recent advances in archaeal translation initiation. Frontiers in Microbiology, section Biology of Archaea. (invited review) Front Microbiol. 2020 Sep 18;11:584152, doi.org/10.3389/fmicb.2020.584152.
     
  • Coureux PD, Lazennec-Schurdevin C, Bourcier S, Mechulam Y, Schmitt E.Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation.
    Commun Biol. (2020) Feb 6;3(1):58, doi.org/10.1038/s42003-020-0780-0.

  • Opuu V, Nigro G, Gaillard T, Schmitt E, Mechulam Y, Simonson T.Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power. PLoS Comput Biol. (2020) Jan 9;16(1):e1007600, doi.org/10.1371/journal.pcbi.1007600. eCollection 2020 Jan.

  •  Nigro G, Bourcier S, Lazennec-Schurdevin C, Schmitt E, Marlière P, Mechulam Y.Use of β3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J Struct Biol. (2019) Dec 17:107435, doi.org/10.1016/j.jsb.2019.107435.

  • Heddi B, Cheong VV, Schmitt E, Mechulam Y, Phan AT. Recognition of different base tetrads by RHAU: X-ray crystal structure of the G4 recognition motif bound to the 3’-end tetrad of a DNA G-quadruplex. Journal of Structural Biology, Elsevier, (2019), pp.S1047-8477(19)30210-2, doi.org/10.1016/j.jsb.2019.10.001.

  • Winnerdy FR, Bakalar B, Maity A, Vandana JJ, Mechulam Y, Schmitt E, Phan AT. NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes. Nucleic Acids Res., (2019), pp.gkz349, doi.org/10.1093/nar/gkz349.

  • Bakalar B, Heddi B, Schmitt E, Mechulam Y, Phan AT. A Minimal Sequence for Left-Handed G-Quadruplex Formation. Angew Chem Int Ed Engl. (2019) Nov 27, doi.org/10.1002/anie.201812628.

  • Monestier A, Lazennec-Schurdevin C, Coureux PD, Mechulam Y, Schmitt E. Role of aIF1 in Pyrococcus abyssi translation initiation. Nucleic Acids Res. (2018), doi.org/10.1093/nar/gky850.

  • Schmitt E, Bourgeois G, Gondry M, Aleksandrov A. Cyclization Reaction Catalyzed by Cyclodipeptide Synthases Relies on a Conserved Tyrosine Residue. Sci Rep. (2018), doi.org/10.1038/s41598-018-25479-5.

  • Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec-Schurdevin, C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Crews CM, Alexandrova AY, Perelmuter VM, Cherdyntseva NV, Bièche I, Schmitt  E, Insall  RH, Gautreau A. A trimeric coiled coil protein promotes WASH complex assembly. EMBO J. (2018), doi.org/10.15252/embj.201797706.

  • Bourgeois G, Seguin J, Babin M, Belin P, Moutiez M, Mechulam Y, Gondry M and Schmitt E. Structural basis for partition of the cyclodipeptide synthases into two subfamilies. J. Struct. Biol. (2018) 203:17-26, doi.org/10.1016/j.jsb.2018.03.001.

  • Monestier A, Aleksandrov A, Coureux PD, Panvert M, Mechulam Y, Schmitt E. The structure of an E. coli tRNAfMet A1-U72 variant shows an unusual conformation of the A1-U72 base pair. RNA. (2017), doi.org/10.1261/rna.057877.116.

  • Coureux PD, Lazennec-Schurdevin C, Monestier A, Larquet E, Cladière L, Klaholz BP, Schmitt E, Mechulam Y. (2016) Cryo-EM study of start codon selection during archaeal translation initiation. Nat Commun. 7:13366, doi.org/10.1038/ncomms13366.