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Eukaryotic and archaeal translation initiation complexes have a common structural core comprising e/aIF1, e/aIF1A, the ternary complex (TC, e/aIF2-GTP-Met-tRNAiMet) and mRNA bound to the small ribosomal subunit. e/aIF2 plays a crucial role in this process but how this factor controls start codon ...
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The 3D structure of Dcp1-Dcp2-Edc3 complex reveals the mechanism of the enzyme responsible for eukaryotic mRNA 5'-cap elimination.
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Collaboration with Regensburg University
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