In the brain of all adult vertebrates, neural stem cells (NSCs) can be recruited to produce new neurons. Here, using two-photon intravital imaging in the zebrafish adult telencephalon we could track and analyze the spatiotemporal pattern of activation and division events of quiescent neural stem cells over 24 days. With spatial statistics and modeling we could demonstrate how a transient local inhibition from neural progenitors generates an intrinsic niche that coordinates NSC recruitment at large scale and long-term.

Reference:
Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain
Dray N, Mancini L, Binshtok U, Cheysson F, Supatto W, Mahou P, Bedu S, Ortica S, Than-Trong E, Krecsmarik M, Herbert S, Masson JB, Tinevez JY, Lang G, Beaurepaire E, Sprinzak D, Bally-Cuif L.
Cell Stem Cell (2021)