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Total Synthesis and Interfaces

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Total synthesis constitutes the main core of Bastien's work. It is connected to the biological interface through bio-inspired methodologies, chemical biology, medicinal chemistry and natural history topics. We try to undertand the chemical origin of the diversity and complexity of natural products, and their underlying biological role with applied perspectives. Bastien takes part to teaching in the Master Molecular Chemistry, Science and Engineering. Bastien is a CNRS researcher ("directeur de recherche") and joined LSO in January 2017 after 12 years spent at the National Museum of Natural History.

Click to know more on recent developments and group background

It's time for PhD applications. Send an email to Bastien.

Group members:

Dr. Bastien Nay [bastien.nay(at)polytechnique(dot)edu]

Oscar Gayraud, PhD student (2017-2020)

Wei Zhang, PhD student (2015-2018, in collaboration with the National Museum of Natural History)

Latests publications:

Bioinspired Adventures in the Total Synthesis of Mixed Polyketide–Nonribosomal Peptide Natural Products
B. Nay,* M. Zaghouani, B. Laroche, S. Prévost, X.-W. Li, A. Ear, N. Riache
in Strategies and Tactics in Organic Synthesis, Vol. 13 (2017), M. Harmata (Ed.), Academic Press-Elsevier, pp. 55-80, DOI: 10.1016/B978-0-12-811790-3.00003-1.


Harnessing the potential diversity of resinic diterpenes through visible light-induced sensitized oxygenation coupled to Kornblum-DeLaMare and Hock reactions
B. Laroche and B. Nay*
Organic Chemistry Frontiers 2017, 4, 2412-2416, DOI: 10.1039/C7QO00633K
Recommended among
Organic Chemistry Frontiers HOT articles for 2017

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A reactive eremophilane and its antibacterial 2(1H)‑naphthalenone rearrangement product, witnesses of a microbial chemical warfare
S. Amand, M. Vallet, L. Guedon, G. Genta-Jouve, F. Wien, S. Mann, J. Dupont, S. Prado* and B. Nay*
Organic Letters 2017, 19(15), 4038–4041, doi: 10.1021/acs.orglett.7b01788 PDF


First Total Synthesis, Structure Revision and Natural History of the Smallest Cytochalasin: (+) Periconiasin G
M. Zaghouani, C. Kunz, L. Guédon, F. Blanchard, B. Nay*
Chemistry – A European Journal 2016, 22, 15257–15260, doi: 10.1002/chem.201603734

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3-Acylated tetramic and tetronic acids as natural metal binders: myth or reality?
M. Zaghouani and B. Nay*
Natural Product Reports 2016, 33, 540-548, DOI: 10.1039/c5np00144g.