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Research topics - organotitanium chemistry

  • Transformation of thioamides with the Ti(OiPr)4/RMgX combination of reagents

Reductive alkylation of thioamides:

The reaction mechanism is likely to involve a metallated iminium intermediate, that can be trapped by a nucleophile.

F. Hermant, E. Urbańska, S. Seizilles de Mazancourt, T. Maubert, E. Nicolas, Y. Six, Organometallics 2014, 33, 5643–5653.

  • Ti(OiPr)4/nBuLi reagent system

Alkyne cyclotrimerisation:

V. A. Rassadin, E. Nicolas, Y. Six, Chem.Commun. 2014, 50, 7666–7669.

  • Cyclopropane chemistry

Electrochemical aerobic oxidations (work conducted in collaboration with Dr Olivier Buriez from ENS in Paris and with the group of Dr Angela Marinetti from ICSN in Gif-sur-Yvette):

The endoperoxides thus synthesised exhibit a moderate antimalarial activity (measured at the National Museum of Natural history in Paris by the group of Dr Isabelle Florent).

F. Nuter, A. K. D. Dimé, C. Chen, L. Bounaadja, E. Mouray, I. Florent, Y. Six, O. Buriez, A. Marinetti, A. Voituriez, Chem. Eur. J. 2015, 21, 5584–5593.

Synthesis of complex nitrogen-containing polycyclic systems:

A. Wasilewska, B. A. Woźniak, G. Doridot, K. Piotrowska, N. Witkowska, P. Retailleau, Y. Six, Chem. Eur. J. 2013, 19, 11759−11567.