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Ursula LIEBL

Chercheuse CNRS
Pièce : 02-2012, 02-2023, 02-2002A
Tél : 01 69 33 50 48
fax : 01 69 33 50 84

ursula.liebl at polytechnique.edu
       

Research topics


Adaptive molecular mechanisms in microbial systems

  • heme-based sensor proteins
  • bacterial gas signaling and transcriptional regulation
  • mechanistic aspects of thymidylate synthase ThyX
  • serine hydroxymethyltransferase in Helicobacter pylori

 

CV


  • depuis 2016          DR1 CNRS
  • 2002-2016            DR2 CNRS
  • 1998-2012            Lecturer (chargée d'enseignement) in biology, E polytechnique
  • 2001                      Habilitation to direct research, U. Paris XI
  • 1993-1995            Post-doc, U. Pennsylvania, Philadelphia, USA
  • 1993                      PhD in biology, U. Regensburg, Germany

 

Selected publications


 

Identification of the TyrOH° radical cation in the flavoenzyme TrmFO

L Nag, P Sournia, H Myllykallio, U Liebl, MH Vos

J Am Chem Soc. 139:11500-11505 (2017).

 

Ultrafast Photochemistry of the bc1 Complex

MH Vos, BJ Reeder, F Daldal, U Liebl

Phys Chem Chem Phys. 19:6807-6813 (2017).

 

Unusual Dynamics of Ligand Binding to the Heme Domain of the Bacterial CO Sensor Protein RcoM-2

L Bouzhir-Sima, R Motterlini, J Gross, MH Vos & U Liebl

J. Phys. Chem. B, 120:10686–10694 (2016).

 

Time-resolved infrared spectroscopic studies of ligand dynamics in the active site from cytochrome c oxidase.

Vos MH, Liebl U

Biochim Biophys Acta, 1847:79-85 (2015).

 

Dynamics of the heme-binding bacterial gas sensing dissimilative nitrate respiration regulator (DNR) and activation barriers for ligand binding and escape.

Lobato L, Bouzhir-Sima L, Yamashita T, Wilson MT, Vos MH & Liebl U

J Biol Chem, 289:26514-24 (2014).

 

Intracellular dynamics of archaeal FANCM homologue Hef in response to halted DNA

replication.

Lestini R. Laptenok S, Kuhn J, Hink MA, Schanne-Klein MC, Liebl U & Myllykallio H

Nucleic Acids Research, 41:10358-70 (2013).

 

Ultrafast real time visualization of the active site flexibility of the flavoenzyme thymidylate synthase ThyX.

SP Laptenok, L Bouzhir-Sima, J-C Lambry, H Myllykallio, U Liebl, MH Vos

Proc Natl Acad Sci U S A. 110:8924-9 (2013).

 

Primary processes in heme-based sensor proteins.

Liebl U, Jean-Christophe Lambry, Vos MH

Biochim. Biophys. Acta Proteins and Proteomics 1834:1684-92 (2013).

 

Mechanistic and structural basis for inhibition of flavin-dependent thymidylate synthase ThyX.

T Basta, Y Boum, J Briffotaux, HF Becker, I Lamarre-Jouenne, J-C Lambry, S Skouloubris, U Liebl, M Graille, H van Tilbeurgh, H Myllykallio

Open Biol. 2(10): 120120 (2012).

 

Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis.

Vos MH, Bouzhir-Sima L, Lambry JC, Luo H, Eaton-Rye JJ, Ioanoviciu A, Ortiz de Montellano PR, Liebl U

Biochemistry 51:159-66 (2012).

 

Heme ligand binding properties and intradimer interactions in the full-length sensor protein dos from Escherichia coli and its isolated heme domain.
Lechauve C, Bouzhir-Sima L,Yamashita T, Marden M, Vos MH, Liebl U, Kiger L
J Biol Chem. 284:36146-59 (2009).

Heme ligand binding properties and intradimer interactions in the full-length sensor protein dos from Escherichia coli and its isolated heme domain.
Lechauve C, Bouzhir-Sima L,Yamashita T, Marden M, Vos MH, Liebl U, Kiger L.
J Biol Chem. 284(52):36146-59 (2009).

Flavin-dependent thymidylate synthase X limits chromosomal DNA replication.
Escartin F, Skouloubris S, Liebl U, Myllykallio H.
Proc Natl Acad Sci U S A. 105(29):9948-52 (2008). 

Ultrafast heme-residue bond formation in six-coordinate heme proteins: implications for functional ligand exchange.
Vos MH, Battistoni A, Lechauve C, Marden MC, Kiger L, Desbois A, Pilet E, de Rosny E, Liebl U.
Biochemistry. 47(21):5718-23 (2008).

Ligand dynamics and early signaling events in the heme domain of the sensor protein Dos from Escherichia coli.
Yamashita T, Bouzhir-Sima L, Lambry JC, Liebl U, Vos MH.
J Biol Chem. 283(4):2344-52 (2008).

Catalytic Mechanism and Structure of Viral Flavin-dependent Thymidylate Synthase ThyX.
Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou C-Z, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U
J. Biol. Chem. 281, 24048-24057 (2006).

Role of Distal Arginine in Early Sensing Intermediates in the Heme Domain of the Oxygen Sensor FixL.
Jasaitis A, Hola K, Bouzhir-Sima L, Lambry J-C, Balland V, Vos MH , Liebl U
Biochemistry 45, 6018-6026 (2006).

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.
Leduc D, Graziani S, Lipowski G, Marchand C, Le Marechal P, Liebl U, Myllykallio H 
Proc Natl Acad Sci U S A. 101, 7252-7257 (2004).

An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis.
Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U 
Science 297, 105-107 (2002).

Ultrafast ligand rebinding in the heme domain of the oxygen sensors FixL and Dos: General regulatory implications for heme-based sensors.
Liebl U, Bouzhir-Sima L, Négrerie M, Martin J-L, Vos MH  
Proc Natl Acad Sci U S A. 99, 12771-12776 (2002).

Coherent reaction dynamics in a bacterial cytochrome c oxidase.
Liebl U, Lipowski G, Négrerie M, Lambry J-C, Martin J-L, Vos MH
Nature 401, 181-184 (1999).