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Hannu Myllykallio

Chercheur / biologie
Professeur chargé de cours à l'Ecole Polytechnique
Rooms : 02-2016b, 02-2003
Tél :+33 (0) 16933 5010/5058
fax :+33 (0) 16933 5084;

hannu.myllykallio at polytechnique.edu
       

Biographical Sketch


2009- Professeur chargé de cours à l'Ecole Polytechnique

2003 Coups d'élan pour la recherche française - Fondation Bettencourt - Schueller

2003 Médaille de Bronze, CNRS (section 22)

2001- Permanent Researcher CNRS (currently DR2)

1998-2001 Post-doc at U. Paris XI (Marie Curie and EMBO Long term Fellow)

1993-1998 PhD in Biology, U. Pennsylvania, Philadelphia, USA)

1991 Masters in Biochemistry, U. Helsinki, Finland
 

Selected publications:


1. Ren B, Kuhn J, Meslet-Cladiere L, Briffotaux J, Norais C, Lavigne R, Flament D, Ladenstein R, Myllykallio H (2009) Structure and function of a novel endonuclease acting on branched DNA substrates. EMBO J 28(16): 2479-2489.

 

2. Escartin F, Skouloubris S, Liebl U, Myllykallio H (2008) Flavin-dependent thymidylate synthase X limits chromosomal DNA replication. Proc Natl Acad Sci U S A 105(29): 9948-9952.

3. Norais C, Hawkins M, Hartman AL, Eisen JA, Myllykallio H, Allers T (2007) Genetic and physical mapping of DNA replication origins in Haloferax volcanii. PLoS Genet 3(5): e77.

4. Meslet-Cladiere L, Norais C, Kuhn J, Briffotaux J, Sloostra JW, Ferrari E, Hubscher U, Flament D, Myllykallio H (2007) A novel proteomic approach identifies new interaction partners for proliferating cell nuclear antigen. J Mol Biol 372(5): 1137-1148.

5. Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U (2006) Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX. J Biol Chem 281(33): 24048-24057.

6. Urbonavicius J, Skouloubris S, Myllykallio H,Grosjean H (2005) Identification of a novel gene encoding aflavin-dependent tRNA:m5U methyltransferase in bacteria--evolutionaryimplications. Nucleic Acids Res 33(13): 3955-3964.

7. Matsunaga F, Norais C, Forterre P, Myllykallio H (2003) Identification of short 'eukaryotic' Okazaki fragments synthesized from a prokaryotic replication origin. EMBO Rep 4(2): 154-158

8. Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U (2002) An alternative flavin-dependent mechanism for thymidylate synthesis. Science 297(5578): 105-107.

9. Matsunaga F, Forterre P, Ishino Y, Myllykallio H (2001) In vivointeractions of archaeal Cdc6/Orc1 and minichromosome maintenanceproteins with the replication origin. Proc Natl Acad Sci U S A 98(20): 11152-11157.

10. Myllykallio H,Lopez P, Lopez-Garcia P, Heilig R, Saurin W, Zivanovic Y, Philippe H,Forterre P (2000) Bacterial mode of replication with eukaryotic-likemachinery in a hyperthermophilic archaeon. Science 288(5474): 2212-2215.

11. Myllykallio H, Zannoni D, Daldal F (1999) The membrane-attachedelectron carrier cytochrome cy from Rhodobacter sphaeroides isfunctional in respiratory but not in photosynthetic electron transfer. Proc Natl Acad Sci U S A 96(8): 4348-4353.