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Designing Original Hybrid nanoColloids, the Examples of Soluble Temperature nanoProbes and of Intraluminal Bowel Retraction

le 13 mai 2016 à 11 h
Pascal André, CERC, Ewha W. University (Seoul, Korea), RIKEN Advanced Science Institute (Wako, Japan)

Hybrid organic-inorganic materials hold promises of complementing one another properties and are a growing component of biomedical research and material engineering. In this presentation we will discuss two examples of such hybrid materials in the context of hyperthermia and surgery applications. It is well established that multimodal nanoparticles (nPs) can be used to design colloids combining optical and magnetics properties suitable for dual imaging. However, stepping aside of imaging we have demonstrates that hybrid nanocolloids can be prepared to carry the basic elements needed to create soluble nanoprobes for remotely sensing temperature of aqueous media. Such multi-modal nanocolloids offer development opportunities for non-invasive and remote absolute temperature optical monitoring suitable for hyperthermia treatments and cell poration.1 The presentation will build on and discuss the synthesis and characterization of biocompatible FePt nPs suitable for biomedical applications.2 To access an area of interest for surgery, the procedures are often associated with mechanical graspers, which however induce tissue trauma.3 To improve patient comfort and recovery, these tissue trauma should be minimized. We will discuss how combining organic component and magnetic nanoparticles can be used for magnetic tissue retraction, and will apply the approach to bowel segments by intraluminal injection.4  


Lieu(x) :         Amphithéatre Grégory, Ecole Polytechnique


Contact :       Antigoni Alexandrou
                      antigoni.alexandrou at polytechnique.edu


À télécharger :       Séminaire ANDRE.pdf - PDF