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Biological ratchets in morphogenesis

le 30 octobre 2019 à 11h

Michel LABOUESSE, Institut de Biologie Paris-Seine (IBPS), CNRS - Sorbonne Université - INSERM, Paris


Lieu(x) :       Amphithéatre Becquerel, Ecole Polytechnique


Contact :    Emmanuel Beaurepaire
                   emmanuel.beaurepaire at polytechnique.edu

During embryonic development the fate of early cells are restricted and the shape of each generated tissue are progressively modified. Mechanical forces can achieve cell deformation, but they are opposed by the intrinsic elasticity of tissues. I will describe how a ratchet process can block transient states of cellular deformations to achieve important morphogenetic changes through small increments, and thereby create order from disorder.
Reference :

Lardennois et al, An actin-based viscoplastic lock ensures progressive body-axis elongation, Nature (2019)

À télécharger : Séminaire LABOUESSE