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Ursula LIEBL

Chercheuse CNRS
Pièce : 02-2012, 02-2023, 02-2002A
Tél : 01 69 33 50 48
fax : 01 69 33 50 84

ursula.liebl at polytechnique.edu
       

Research topics


Adaptive molecular mechanisms in microbial systems

  • heme-based sensor proteins
  • mechanistic aspects of thymidylate synthase ThyX
  • serine hydroxymethyltransferase in Helicobacter pylori

 

CV


  • 2002-present DR2 CNRS
  • 1998-present Lecturer (chargée d'enseignement) in biology, E polytechnique
  • 2001 Habilitation to direct research, U. Paris XI
  • 1993-1995 Post-doc, U. Pennsylvania, Philadelphia, USA
  • 1993 PhD in biology, U. Regensburg, Germany

 

Selected publications


Heme ligand binding properties and intradimer interactions in the full-length sensor protein dos from Escherichia coli and its isolated heme domain.
Lechauve C, Bouzhir-Sima L,Yamashita T, Marden M, Vos MH, Liebl U, Kiger L.
J Biol Chem. 284(52):36146-59 (2009).

Flavin-dependent thymidylate synthase X limits chromosomal DNA replication.
Escartin F, Skouloubris S, Liebl U, Myllykallio H.
Proc Natl Acad Sci U S A. 105(29):9948-52 (2008). 

Ultrafast heme-residue bond formation in six-coordinate heme proteins: implications for functional ligand exchange.
Vos MH, Battistoni A, Lechauve C, Marden MC, Kiger L, Desbois A, Pilet E, de Rosny E, Liebl U.
Biochemistry. 47(21):5718-23 (2008).

Ligand dynamics and early signaling events in the heme domain of the sensor protein Dos from Escherichia coli.
Yamashita T, Bouzhir-Sima L, Lambry JC, Liebl U, Vos MH.
J Biol Chem. 283(4):2344-52 (2008).

Catalytic Mechanism and Structure of Viral Flavin-dependent Thymidylate Synthase ThyX.
Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou C-Z, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U
J. Biol. Chem. 281, 24048-24057 (2006).

 

 

 

 

 

 

Role of Distal Arginine in Early Sensing Intermediates in the Heme Domain of the Oxygen Sensor FixL.
Jasaitis A, Hola K, Bouzhir-Sima L, Lambry J-C, Balland V, Vos MH , Liebl U
Biochemistry 45, 6018-6026 (2006).

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.
Leduc D, Graziani S, Lipowski G, Marchand C, Le Marechal P, Liebl U, Myllykallio H 
Proc Natl Acad Sci U S A. 101, 7252-7257 (2004).

 

 

An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis.
Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U 
Science 297, 105-107 (2002).

 

Ultrafast ligand rebinding in the heme domain of the oxygen sensors FixL and Dos: General regulatory implications for heme-based sensors.
Liebl U, Bouzhir-Sima L, Négrerie M, Martin J-L, Vos MH  
Proc Natl Acad Sci U S A. 99, 12771-12776 (2002).

Coherent reaction dynamics in a bacterial cytochrome c oxidase.
Liebl U, Lipowski G, Négrerie M, Lambry J-C, Martin J-L, Vos MH
Nature 401, 181-184 (1999).