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DNA G-quadruplexes d'ADN can interact with SARS-Cov-2

The SARS-CoV-2 virus codes for several proteins, including Nsp3. A part of this protein, the SUD-NM domain, is able to bind to G-quadruplexes, an unusual nucleic acid structure formed by Guanine rich RNA and DNA sequences). Interaction is specific, as shown by a fluorescent-based method. These results, obtained by a collaboration involving LOB researchers were published in Nucleic Acids Research (2021).