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Liste des publications

# Corresponding author.


  • Charenton C, Graille M#. (2018) mRNA decapping: finding the right structures. Philos Trans R Soc Lond B Biol Sci. doi: 10.1098/rstb.2018.0164
  • Tran NV; Muller L; Ross RL; Lestini R; Létoquart J; Ulryck N; Limbach PA; de Crécy-Lagard V; Cianferani S; Graille M#. (2018) Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes. Nucleic Acids Res,  46(16), 8483-8499. doi: 10.1093/nar/gky638



  • Charenton C; Gaudon-Plesse C; Fourati Z; Taverniti V; Back R; Kolesnikova O; Séraphin B#; Graille M#. (2017) A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5'-3' mRNA exonuclease in yeast. Proc Natl Acad Sci U S A, 114(45), E9493-9501. doi: 10.1073/pnas.1711680114
  • Bourgeois G; Létoquart J; van Tran N; Graille M#. (2017) Trm112, a protein activator of methyltransferases modifying actors of the eukaryotic translational appartus. Biomolecules7(1), E7. doi: 10.3390/biom7010007
  • Bourgeois G; Marcoux J; Saliou JM; Cianférani S; Graille M#. (2017) Activation mode of the eukaryotic m2G10 tRNA methyltransferase Trm11 by its partner protein Trm112. Nucleic Acids Res, 45(4), 1971-1982. doi: 10.1093/nar/gkw1271



    • Charenton C, Taverniti V, Gaudon-Plesse C, Back R, Séraphin B#, Graille M#. (2016), Structure of the active form of Dcp1-Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator. Nat. Struct. Mol. Biol. Oct 3.; 23(11); 982-96. doi: 10.1038/nsmb.3300



    • Létoquart J, Tran N.V, Caroline V, Alexandrov A, Lazar N, van Tilbeurgh H, Liger D#, Graille M#. (2015) Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure. Nucleic Acids Res43(22), 10989-11002.
    • Blondeau K; Blaise F; Graille M; Kale S; Linglin J; Ollivier B; Labarde A; Lazar N; Daverdin G; Balesdent MH; Choi D; Tyler B; Rouxel T; van Tilbeurgh H; Fudal I. (2015) Crystal structure of the effector AvrLm4-7 of Leptosphaeria maculans reveals insights into its translocation into plant cell and recognition by resistance proteins. The Plant Journal; 83(4), 610-24.
    • Zhang W; Collinet B; Graille M; Daugeron MC; Lazar N; Libri D; Durand D; van Tillbeurgh H. (2015) Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. Nucleic Acids Res. 43(6), 3358-72.



    • Létoquart J ; Huvelle E ; Wacheul L ; Bourgeois G ; Zorbas C ; Graille M# ; Heurgué-Hamard V# ; Lafontaine D.L.J#. (2014) Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes. Proc Natl Acad Sci U S A. 111(51), E5518-26.
    • Fourati Z ; Roy B ; Millan C ; Coureux PD ; Kervestin S ; van Tilbeurgh H ; He F ; Uson I ; Jacobson A# ; Graille M#. (2014) A highly conserved region essential for NMD in the Upf2 N-terminal domain. J Mol. Biol. 426(22), 3689-3702.
    • Fourati Z ; Kolesnikova O ; Back R ; Keller J ; Charenton C ; Taverniti V ; Gaudon Plesse C ; Lazar N ; Durand D ; van Tilbeurgh H ; Séraphin B# ; Graille M#. (2014) The C-terminal domain from S. cerevisiae Pat1 displays two conserved regions involved in decapping factor recruitment. Plos One, 9(5), e96828.
    • Fourati Z & Graille M. (2014) Cytoplasmic mRNA surveillance pathways. In « Fungal RNA biology » (Springer International Publishing). Editors : A. Sesma and T. von der Haar. ISBN 978-3-319-05687-6. (Book chapter)
    • Boudes M ; Sanchez D ; Graille M ; van Tilbeurgh H ; Durand D ; Quevillon-Cheruel S. (2014) Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae. Nucleic Acids Res, 42(8), 5302-5313.
    • Tiouajni M ; Durand D ; Blondeau K ; Graille M ; Urvoas A ; Valerio-Lepiniec M ; Guellouz A ; Aumont-Nicaise M ; Minard P ; van Tillbeurgh H. (2014) Structural and functional analysis of the fibronectin binding protein FNE from Streptococcus equi subsp. Equi. FEBS Journal. 281(24), 5513-31.



    • Kolesnikova O ; Back R ; Graille M ; Séraphin B. (2013) Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay. Nucleic Acids Res, 41(20), 9514-9523.
    • Guellouz A ; Valerio-Lepiniec M ; Urvoas A ; Chevrel A ; Graille M ; Fourati-Kammoun Z ; Desmadril M ; van Tilbeurgh H ; Minard P. (2013) Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep). Plos One, 8(8), e71512.
    • Leulliot N, Quevillon-Cheruel C, Graille M, Geslin C, Flament D, Le Romancer M, van Tilbeurgh H. (2013) Crystal structure of PAV1-137, a protein from the virus PAV1 that infects Pyrococcus abyssi. Archaea, article ID : 568053



    • Graille M#, Séraphin B#. (2012) Surveillance pathways rescuing eukaryotic ribosomes lost in translation. Nat. Rev. Mol. Cell Biol., 13, 727-735 (Review).
    • Figaro S, Wacheul L, Schillewaert S, Graille M, Huvelle E, Mongeard R, Zorbas C, Lafontaine DLJ, Heurgué-Hamard. (2012) Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575. Mol. Cell. Biol. 32(12), 2254-67.
    • Graille M#, Figaro S, Kervestin, S, Buckingham RH, Liger D, Heurgué-Hamard V#. (2012) Methylation of class I translation termination factors : structural and functional aspects. Biochimie. 94, 1533-43 (Review).
    • Barreteau H, Tiouajni M, Graille M, Josseaume, Bouhss A, Patin D, Blanot D, Fourgeaud M, Mainardi JL, Arthur M, van Tilbeurgh H, Mengin-Lecreulx D, Touzé T. (2012) Functional and structural characterization of PaeM, a colicin M-like bacteriocin produced by Pseudomonas aeruginosa. J Biol Chem, 287(44), 37395-37405.
    • Basta T, Boum Y, Briffotaux J, Becker H, Lamarre I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. (2012) Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biology. 2(10), 120120
    • Boudes M, Lazar N, Graille M, Durand D, Gaidenko TA, Stewart V, van Tilbeurgh H. (2012) The structure of the NasR transcription antiterminator reveals a one-component system with a NIT nitrate-receptor coupled to an ANTAR RNA-binding effector. Mol. Microbiol. 85(3), 431-444.



    • Rispal D, Henri J, van Tilbeurgh H, Graille M#, Séraphin B#. (2011) Structural and functional analysis of Nro1/Ett1 : a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe. RNA. 17(7), 1213-24.
    • Liger D, Mora L, Lazar N, Figaro S, Henri J, Scrima N, Buckingham RH, van Tilbeurgh H, Heurgué-Hamard V#, Graille M#. (2011) Mechanism of activation of methyltransferases involved in translation by the Trm112 « hub » protein. Nucleic Acids Res. 39(14), 6249-59.
    • Collinet B, Friberg A, Brooks MB, van den Elzen AMG, Henriot V, Dziembowski A, Graille M, Durand D, Leulliot N, Saint-André C, Lazar N, Sattler M, Séraphin B, van Tilbeurgh H. (2011) Strategies for the structural analysis of multi-protein complexes : lessons from the 3D-Repertoire project. J. Struct. Biol. 175(2), 147-58.
    • Gérard F, Brooks, MA, Barreteau H, Touzé T, Graille M, Bouhss A, Blanot D, van Tilbeurgh H, Mengin-Lecreulx D. (2011) X-ray structure and site-directed mutagenesis analysis of the E. coli colicin M immunity protein. J. Bact. 193(1), 205-14.



    • van den Elzen AMG, Henri J, Lazar N, Gas-Lopez M, Durand D, Lacroute F, NicaiseM, van Tilbeurgh H, Séraphin B#, Graille M#. (2010) Dissection of Dom34-Hbs1 reveals independent functions in two RNA quality control pathways. Nat. Struct. Mol. Biol. 17(12), 1446-53.
    • Henri J, Rispal D, Bayart E, van Tilbeurgh H, Séraphin B#, Graille M#. (2010) Structural and functional insights into S. cerevisiae Tpa1, a putative prolyl hydroxylase influencing translation termination and transcription. J Biol Chem, 285(40), 30767-78.
    • Graille M#, Pagano M, Rose T, Reboud Ravaux M, van Tilbeurgh H#. (2010) Zinc induces structural reorganization of the gelatin binding domain from human fibronectin and affects collagen binding. Structure, 18, 710-8.
    • Urvoas A, Guellouz A, Valerio-Lepiniec M, Graille M, Durand D, Desravines DC, van Tilbeurgh H, Desmadril D, Minard P (2010) Design, production and molecular structure of a new family of artificial alpha helicoidal repeat proteins (alpha-Rep) based on thermostable HEAT-like repeats. J Mol. Biol. 404, 307-27.



    • Hecker A, Graille M, Madec E, Gadelle D, Le Cam E, van Tilbergh H, Forterre P. (2009) The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya. Biochem Soc Trans. 37(Pt 1), 29-35. (Peer-reviewed meeting proceedings)



    • Graille M#, Chaillet M, van Tilbeurgh H. (2008) Structure of yeast Dom34 : a protein related to translation termination factor eRF1 and involved in No-Go decay. J Biol Chem. 283(11), 7145-54.
    • Graille M, Cladière L, Durand D, Lecointe F, Gadelle D, Quevillon-Cheruel S, Vachette P, Forterre P, van Tilbeurgh H. (2008) Crystal structure of an intact type II DNA topoisomerase : insights into DNA transfer mechanisms. Structure. 16(3), 360-70.
    • Leulliot N, Bohnsack MT, Graille M, Tollervey D, van Tilbeurgh H. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res. 36(2), 629-39.
    • Hecker A, Lopreiato R, Graille M, Collinet B, Forterre P, Libri D, van Tilbeurgh H. (2008) Structure of the archaeal Kae1/Bud32 fusion protein MJ1130 : a model for the eukaryotic EKC/KEOPS subcomplex. EMBO J. 27, 2340-51.
    • Durand F, Dagkessamanskaia A, Martin-Yken H, Graille M, van Tilbeurgh H, Uversky VN, François JM. (2008) Structure-function analysis of Knr4/Smi1, a newly member of intrinsically disordered proteins family, indispensable in the absence of a functional PKC1-SLT2 pathway in Saccharomyces cerevisiae. Yeast. 25(8), 563-76.
    • Brooks MA, Meslet-Cladière L, Graille M, Myllykallio H, van Tilbeurgh H. (2008) The structure of an archaeal homodimeric ligase which has RNA circularization activity. Protein Sci. 17(8), 1336-45.



    • Hecker A, Leulliot N, Gadelle D, Graille M, Justome A, Dorlet P, Brochier C, Quevillon-Cheruel S, Le Cam E, van Tilbeurgh H, Forterre P. (2007) An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro. Nucleic Acids Res. 35(18), 6042-51.



    • Heurgué-Hamard V, Graille M, Scrima N, Ulryck N, Champ S, van Tilbeurgh H, Buckingham RH. (2006) The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. J Biol Chem. 281(47), 36140-8.
    • Graille M, Baltaze JP, Leulliot N, Liger D, Quevillon-Cheruel S, van Tilbeurgh H. (2006) Structure-based functional annotation : Yeast ymr099cp codes for a D-hexose-6-phosphate mutarotase. J Biol Chem. 281(40), 30175-85.
    • Drevelle A, Graille M, Heyd B, Sorel I, Ulryck N, Pecorari F, Desmadril M, van Tilbeurgh H, and Minard P. (2006) Structures of in vitro evolved binding sites on Neocarzinostatin scaffold reveal unanticipated evolutionary pathways. J Mol. Biol. 358(2), 455-71.
    • Gadelle D, Graille M, Forterre P. (2006) The Hsp90 and DNA topisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase. Biochem. Pharmacol. 72(10), 1207-16.
    • Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, and Liebl U. (2006) Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX. J Biol. Chem. 281(33), 24048-57.
    • Quevillon-Cheruel, S, Leulliot, N, Graille M, Blondeau, K, Janin, J and van Tilbeurgh, H. (2006) Crystal structure of the yeast His6 enzyme suggests a reaction mechanism. Protein Sci. 15(6), 1516-21.



    • Graille M, Heurgue-Hamard V, Champ S, Mora L, Scrima N, Ulryck N, van Tilbeurgh H, Buckingham RH. (2005) Molecular Basis for Bacterial Class I Release Factor Methylation by PrmC. Mol. Cell. 20(6), 917-27.
    • Leulliot N, Quevillon-Cheruel S, Graille M, Schiltz M, Blondeau K, Janin J, Van Tilbeurgh H. (2005) Crystal structure of yeast YER010Cp, a knotable member of the RraA protein family. Protein Sci. 14(10), 2751-8.
    • Gadelle D, Bocs C, Graille M, Forterre P. (2005) Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Res. 33(7), 2310-7.
    • Graille M, Meyer P, Leulliot N, Sorel I, Janin J, van Tilbeurgh H, Quevillon-Cheruel S. (2005) Crystal structure of the S. cerevisiae D-ribose-5-phosphate isomerase : comparison with the archeal and bacterial enzymes. Biochimie. 87(8), 763-9.
    • Quevillon-Cheruel S, Leulliot N, Graille M, Hervouet N, Coste F, Benedetti H, Zelwer C, Janin J, van Tilbeurgh H. (2005) Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. Protein Sci. 14(5), 1350-6.
    • Graille M, Zhou CZ, Receveur-Brechot V, Colinet B, Declerck N, van Tilbeurgh H. (2005) Activation of the LicT transcriptional antiterminator involves a domain swing/lock mechanism provoking massive structural changes. J. Biol. Chem. 280(15), 14780-9.
    • Zhou CZ, Meyer M, Quevillon-Cheruel S, Li de La Sierra-Gallay I, Collinet B, Graille M, Blondeau K, François JM, Leulliot N, Sorel I, Poupon A, Janin J, van Tilbeurgh H. (2005) Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold. Protein Sci. 14(1), 209-15.
    • Graille M, Stura EA, Bossus M, Muller BH, Letourneur O, Battail-Poirot N, Sibai G, Gauthier M, Rolland D, Le Du MH, Ducancel F. (2005) Crystal structure of the complex between the monomeric form of Toxoplasma gondii surface antigen 1 (SAG1) and a monoclonal antibody that mimics the human immune response. J. Mol. Biol. 354(2), 447-58.
    • Dubreuil O, Bossus M, Graille M, Bilous M, Savatier A, Jolivet M, Ménez A, Stura E, Ducancel F. (2005) Fine-tuning of the specificity of an anti-progesterone antibody by first and second sphere residues engineering. J. Biol. Chem. 280(26), 24880-7.
    • Prilusky J, Oeuillet E, Ulryck N, Pajon A, Bernauer J, Krimm I, Quevillon-Cheruel S, Leulliot N, Graille M, Liger D, Tresaugues L, Sussman JL, Janin J, van Tilbeurgh H, Poupon A. (2005) HalX : an open-source LIMS (Laboratory Information Management System) for small to large scale labs. Acta Crystallogr D Biol Crystallogr. 61(Pt 6), 671-8. (Peer-reviewed meeting proceedings)
    • Leulliot N, Trésaugues L, Bremang M, Sorel I, Ulryck N, Graille M, Aboulfath I, Liger D, Quevillon-Cheruel S, Janin J, van Tilbeurgh H. (2005) High throughput crystal optimisation strategies in the South-Paris Yeast Structural Genomics project : one size fits all ? Acta Crystallogr D Biol Crystallogr. 61(Pt 6), 664-70. (Peer-reviewed meeting proceedings)



    • Graille M, Mora L, Buckingham RH, van Tilbeurgh H, de Zamaroczy M. (2004) Structural inhibition of the colicin D tRNase by the tRNA-mimicking immunity protein. EMBO J. 23(7), 1474-82.
    • Graille M, Quevillon-Cheruel S, Leulliot N, Zhou C-Z, Li de La Sierra Gallay I, Jacquamet L, Ferrer J-L, Liger D, Poupon A, Janin J, van Tilbeurgh H. (2004) Crystal structure of the YDR533c S. cerevisiae protein, a class II member of the Hsp31 family. Structure. 12(5), 839-47.
    • Liger D, Graille M, Zhou CZ, Leulliot N, Quevillon-Cheruel S, Blondeau K, Janin J, van Tilbeurgh H. (2004) Crystal structure and functional characterization of yeast YLR011wp, an enzyme with NAD(P)H-FMN and ferric iron reductase activities. J. Biol. Chem. 279(33), 34890-7.
    • Leulliot N, Quevillon-Cheruel S, Graille M, van Tilbeurgh H, Leeper TC, Godin KS, Edwards TE, Sigurdsson ST, Rozenkrants N, Nagel RJ, Ares M, Varani G. (2004) A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. EMBO J. 23(13), 2468-77.
    • Leulliot N, Quevillon-Cheruel S, Sorrel I, Graille M, Meyer P, Liger D, Blondeau K, Janin J, van Tilbeurgh H. (2004) Crystal structure of yeast allantoicase reveals a repeated jelly-roll motif.” J. Biol. Chem. 279(22), 23447-52.
    • Leulliot N, Quevillon-Cheruel S, Sorel S, Li de La Sierra-Gallay I, Collinet B, Graille M, Blondeau K, Bettache N, Poupon A, Janin J, van Tilbeurgh H. (2004) Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2A activity. J. Biol. Chem. 279(9), 8351-8.
    • Li de la Sierra-Gallay I, Collinet B, Graille M, Quevillon-Cheruel S, Liger D, Minard P, Blondeau K, Henckes G, Aufrère R, Leulliot N, Zhou CZ, Sorel I, Ferrer JL, Poupon A, Janin J, van Tilbeurgh H. (2004) Crystal structure of the YGR205w protein from Saccharomyces cerevisiae : close structural resemblance to E. coli panthotenate kinase. Proteins : Structure, Function and Genetics. 54(4), 776-83.
    • Quevillon-Cheruel S, N. Leulliot N, Meyer P, Graille M, Bremang M, Blondeau K, Sorel I, Poupon A, Janin J, van Tilbeurgh H. (2004) Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae. J. Biol. Chem. 279(1), 619-25.
    • Housden NG, Harrison S, Housden HR, Thomas KA, Beckingham JA, Roberts SE, Bottomley SP, Graille M, Stura EA, Gore MG. (2004) Observation and characterization of the interaction between a single immunoglobulin binding domain of protein L and two human kappa light chains. J. Biol. Chem. 279(10), 9370-8.
    • Quevillon-Cheruel S, Liger D, Leulliot N, Graille M, Poupon A, Li de la Sierra-Gallay I, Zhou CZ, Collinet B, Janin J, van Tilbeurgh H. (2004) The Paris-Sud yeast structural genomics pilot-project : from structure to function. Biochimie. 86(9-10), 617-23. (Peer-reviewed meeting proceedings)



    • Zhou CZ, Li De La Sierra-Gallay I, Quevillon-Cheruel S, Collinet B, Minard P, Blondeau K, Henkes G, Aufrere R, Leulliot N, Graille M, Sorel I, Savarin P, De La Torre F, Poupon A, Janin J, van Tilbeurgh H. (2003) Crystal structure of the yeast Phox Homology (PX) -domain protein Grd19p complexed to Phosphatidylinositol-3-phosphate. J. Biol. Chem. 278(50), 50322-9.
    • Housden NG, Harrison S, Roberts SE, Beckingham JA, Graille M, Stura E, Gore MG. (2003) Immunoglobulin-binding domains : Protein L from Peptostreptococcus magnus. Biochem Soc Trans. 31(Pt 3), 716-8. (Peer-reviewed meeting proceedings)



    • Graille M, Harrison S, Crump MP, Findlow SC, Housden NG, Muller BH, Battail-Poirot N, Sibai G, Sutton BJ, Taussig MJ, Jolivet-Reynaud C, Gore MG, Stura EA. (2002) Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface. J. Biol. Chem. 277(49), 47500-6.
    • Stura EA, Graille M, Housden NG, Gore MG. (2002) Protein L mutants for the crystallization of antibody fragments. Acta Crystallogr D Biol Crystallogr. 58 (Pt 10 Pt 1), 1744-8. (Peer-reviewed meeting proceedings)



    • Graille M, Stura EA, Housden NG, Beckingham JA, Bottomley SP, Beale D, Taussig MJ, Sutton BJ, Gore MG, Charbonnier JB. (2001) Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins. Structure. 9(8), 679-87.
    • Stura EA, Graille M, Charbonnier JB. (2001) Crystallization of Macromolecular Complexes : combinatorial complex crystallization. Journal of Crystal Growth 232, 573-9. (Peer-reviewed meeting proceedings)
    • Stura EA, Graille M, Taussig MJ, Sutton BJ, Gore MG, Silverman GJ, Charbonnier JB. (2001) Crystallization of Macromolecular Complexes : stœchiometric variation screening. Journal of Crystal Growth 232, 580-90. (Peer-reviewed meeting proceedings)



    • Graille M, Stura EA, Corper AL, Sutton BJ, Taussig MJ, Charbonnier JB, Silverman GJ. (2000) Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody : structural basis for recognition of B-cell receptors and superantigen activity. Proc Natl Acad Sci U S A. 97(10), 5399-404.
    • Silverman GJ, Cary S, Graille M, Curtiss VE, Wagenknecht R, Luo L, Dwyer D, Goodyear C, Corper AL, Stura EA, Charbonnier JB. (2000) A B-cell superantigen that targets B-1 lymphocytes. Curr Top Microbiol Immunol. 252, 251-63. (Peer-reviewed meeting proceedings)