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Publications

Recent publications of the team :

  • Monestier A, Lazennec-Schurdevin C, Coureux PD, Mechulam Y, Schmitt E. Role of aIF1 in Pyrococcus abyssi translation initiation. Nucleic Acids Res. (2018) doi: 10.1093/nar/gky850.
  • Schmitt E, Bourgeois G, Gondry M, Aleksandrov A. Cyclization Reaction Catalyzed by Cyclodipeptide Synthases Relies on a Conserved Tyrosine Residue. Sci Rep. (2018) doi: 10.1038/s41598-018-25479-5.
  • Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec-Schurdevin, C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Crews CM, Alexandrova AY, Perelmuter VM, Cherdyntseva NV, Bièche I, Schmitt  E, Insall  RH, Gautreau A. A trimeric coiled coil protein promotes WASH complex assembly. EMBO J. (2018).  doi: 10.15252/embj.201797706.
  • Bourgeois G, Seguin J, Babin M, Belin P, Moutiez M, Mechulam Y, Gondry M and Schmitt E. Structural basis for partition of the cyclodipeptide synthases into two subfamilies. J. Struct. Biol. (2018) 203:17-26. doi: 10.1016/j.jsb.2018.03.001.
  • Monestier A, Aleksandrov A, Coureux PD, Panvert M, Mechulam Y, Schmitt E. The structure of an E. coli tRNAfMet A1-U72 variant shows an unusual conformation of the A1-U72 base pair. RNA. (2017) doi: 10.1261/rna.057877.116.
  • Coureux PD, Lazennec-Schurdevin C, Monestier A, Larquet E, Cladière L, Klaholz BP, Schmitt E, Mechulam Y. (2016) Cryo-EM study of start codon selection during archaeal translation initiation. Nat Commun. 7:13366. doi: 10.1038/ncomms13366.
  • Panvert M, Dubiez E, Arnold L, Perez J, Mechulam Y, Seufert W, Schmitt E. (2015) Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features. Structure. 23:1596-1608.
  • Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT. (2015) Structure of a left-handed DNA G-quadruplex. Proc Natl Acad Sci U S A.,112. 2729-2733.
  • Dubiez E, Aleksandrov A, Lazennec-Schurdevin C, Mechulam Y, Schmitt E. (2015) Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2. Nucleic Acids Res., 43. 2946-2957.
  • Moutiez M, Schmitt E, Seguin J, Thai R, Favry E, Belin P, Mechulam Y, Gondry M. (2014). Unravelling the mechanism of non-ribosomal peptide synthesis by cyclodipeptide synthases. Nat Commun., 5:5141.
  • Jacquier H, Birgy A, Le Nagard H, Mechulam Y, Schmitt E, Glodt J, Bercot B, Petit E, Poulain J, Barnaud G, Gros PA, Tenaillon O (2013). Capturing the mutational landscape of the beta-lactamase TEM-1. Proc Natl Acad Sci U S A, 110(32):13067-72.
  • Naveau M, Lazennec-Schurdevin C, Panvert M, Dubiez E, Mechulam Y, Schmitt E (2013). Roles of yeast eIF2α and eIF2β subunits in the binding of the initiator methionyl-tRNA. Nucleic Acids Res., 41(2):1047-57.
  • E. Schmitt, M. Panvert, C. Lazennec-Schurdevin, P-D Coureux, J. Perez, A. Thompson and Y. Mechulam (2012). Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA. Nature Structural and Molecular Biology, Nat. Struct. Mol. Biol., 9, 450-45.
  • Schmitt E, Naveau M, Mechulam Y. (2010). Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier. FEBS Lett. 584:405-12. Invited review. 
  • Naveau M, Lazennec-Schurdevin C, Panvert M, Mechulam Y, Schmitt E. (2010). tRNA binding properties of eukaryotic initiation factor 2 from Encephalitozoon cuniculi. Biochemistry, 49:8680-8688.
  • Barraud P, Schmitt E, Mechulam Y, Dardel F, Tisné C. (2008). A unique conformation of the anticodon stem-loop is associated with the capacity of tRNAfMet to initiate protein synthesis. Nucleic Acids Res.36:4894-901.
  • Mechulam Y, Guillon L, Yatime L, Blanquet S and Schmitt E (2007).  Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors. Methods Enzymol. 430, « Translation Initiation: Reconstituted Systems and Biophysical Methods ».  Jon Lorsch ed.. 265-281.
  • Yatime, L., Mechulam, Y., Blanquet, S. and  Schmitt, E. (2007). Structure of an archaeal heterotrimeric initiation factor 2 reveals a novel nucleotide state between the GTP and the GDP ones". PNAS, 104, 18445-18450
  • Guillon, L., Schmitt, E., Blanquet, S. and Mechulam, Y. (2005). Initiator tRNA binding by e/aIF5B, the eukaryotic/archaeal homologue of bacterial initiation factor IF2. Biochemistry, 44, 15594-15601.
  • Yatime, L., Mechulam, Y., Blanquet, S. and  Schmitt, E. (2006) Structural switch of the g subunit in an archaeal aIF2ag heterodimer. Structure, 14, 119-128.
  • Yatime, L., Schmitt, E., Blanquet, S. and Mechulam, Y.(2005). Structure-function relationships of the intact aIF2alpha subunit from the archaeon Pyrococcus abyssi  Biochemistry.44, 8749-8756.
  • L. Yatime, E. Schmitt, S. Blanquet, Y.Mechulam. (2004). Functional molecular mapping of archaeal translation initiation factor 2. J. Biol. Chem.  279, 15984-15993. 
  • Schmitt, E., Blanquet, S. & Mechulam, Y. (2002). The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors. EMBO J. 21: 1821-1832.